Magnetic resonance elastography of the brain

Implementation of Magnetic Resonance Elastography for the Investigation of Traumatic Brain Injuries

Brain Viscoelasticity Measured by Magnetic Resonance Elastography

The knowledge of brain tissue mechanical properties is a critical issue in the head injury biomechanics research field. Due to experimental limitations, brain tissue has been characterized in vitro, whereas its actual in vivo behavior remains poorly known. We propose the use of Magnetic Resonance Elastography as a non invasive, non destructive tool for measuring the viscoelastic properties of b...

Viscoelastic Modeling of Brain MRE Data Using FE Method

Dynamic shear test on simulated phantom can be used to validate magnetic resonance elastography (MRE) measurements. Phantom gel has been usually utilized for the cell culture of cartilage and soft tissue and also been used for mechanical property characterization using imaging systems. The viscoelastic property of the phantom would be important for dynamic experiments and analyses. In this stud...

Poroelastic MRE reconstructions of brain acquired with intrinsic activation

Introduction: Recently, magnetic resonance elastography (MRE) of the brain has shown significant promise. Strong results with MS have shown the potential of MRE in the brain. One disadvantage is that eliciting shear waves deep in brain tissue is difficult because the skull and cerebral meninges form an excellent shock absorbing system that effectively isolates the brain from vibrations. Interes...

Decrease of brain stiffness compared to loss of brain volume in Multiple Sclerosis patients

Background: Chronic inflammatory diseases of the CNS such as Multiple Sclerosis (MS) lead to demyelinization and to widespread degradation of neurons and axons. The loss of neurons and axons alters the mechanical structure and therefore the elasticity of the brain, a process which may be useable for early recognition of diffuse pathological degeneration [1]. Problem: Current knowledge of biomec...

MR elastography and MRI volumetry of the aging brain

Background: Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes [1]. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties, which are characterized by mechanical parameters such as stiffness and internal friction. To date Magnetic Resonance Elastography (MRE) is the only non-invasive technique for ...